I do scientific research and Opus5.5 refuses to touch anything I’ve been working on.

A scientist using Claude for research expressed disappointment with the new Opus5.5 model. They had hoped it would resolve quality issues from previous versions, but found that it refused to process their files or provide status updates on new sessions, leading to frustration among other optimistic scientists.

This report is among the first user accounts detailing specific functional regressions in Opus5.5, unlike general quality complaints about prior models.