AlphaGenome Atlas predictive map of every DNA letter change in the human genome

The AlphaGenome Atlas, published in Science on September 8, 2026, provides a predictive map of every DNA letter change in the human genome. It precomputes effects for over 9 billion single-nucleotide variants, deriving an allelic-resolution AlphaGenome Variant Impact (AVI) score for each. This score is decomposed into additive feature contributions across categories like chromatin accessibility and splicing. These precomputed effects, AVI scores, and feature attributions are linked with a compendium of genome-wide de novo motifs, offering high-resolution mechanistic insights into variant function and can be integrated into systems like Google Antigravity.